Memory

A twist on the genetic link between Alzheimer’s and heart disease

Julie Corliss
Julie Corliss, Executive Editor, Harvard Heart Letter

Although the two conditions seem unrelated, Alzheimer’s and heart disease actually share a genetic link. People who have a certain gene variant have both a somewhat elevated heart disease risk and a significantly elevated Alzheimer’s risk. Fortunately, a recent study has suggested that when people know they have this variant, they’re more likely to make healthy lifestyle choices that benefit their heart — and what’s good for the heart is good for the brain.

Can a heartburn drug cause cognitive problems?

Matthew Solan
Matthew Solan, Executive Editor, Harvard Men's Health Watch

Many older adults take PPIs to treat heartburn, GERD, or stomach ulcers. Recently, a new study identified a link between chronic PPI use and an increased risk for dementia. If you take a PPI, check in with your doctor — you may be able to take it only when you have symptoms, not continuously (and this kind of usage was not associated with a dramatically increased dementia risk in the study).

Decline in dementia rate offers “cautious hope”

Beverly Merz
Beverly Merz, Executive Editor, Harvard Women's Health Watch

Last year, the Alzheimer’s Association predicted that rates of dementia would continue to rise. However, a report recently published in the New England Journal of Medicine found that rates of dementia have actually dropped steadily over the past three decades. Whether the drop in rates applies to everyone, and whether it will continue, remain to be seen. But the evidence also confirms that there’s quite a lot you can do to lower your dementia risk.

Challenge your mind and body to sharpen your thinking skills

Heidi Godman
Heidi Godman, Executive Editor, Harvard Health Letter

Mental and social engagement can help keep your brain sharp and lower the chances of cognitive decline, in part because challenging our brains may help forge new connections between brain cells. The key to taking advantage of the brain’s malleability is to find activities that you truly enjoy and to commit to life-long learning.

Getting closer to understanding how exercise keeps brains young

Howard LeWine, M.D.
Howard LeWine, M.D., Chief Medical Editor, Internet Publishing, Harvard Health Publications

A new study published in PLOS One, looked at oxygen related changes and nerve processing in the brain, features that have shown to correlate with better memory and brain function as people age. It found that people with higher fitness levels were the same ones that were more physically active during the week. They were also the same people who showed more positive oxygen related changes and MRI findings consistent with faster nerve processing in the brain. Though there isn’t an exact exercise prescription to guide how long and hard we should exercise, the results of this study and many others, show even low intensity activity for an hour a day is much better for the brain than sitting on the couch.

Mediterranean diet may help counteract age-related declines in memory and thinking skills

Julie Corliss
Julie Corliss, Executive Editor, Harvard Heart Letter

Can a Mediterranean-type diet with extra servings of nuts and extra-virgin olive oil help protect memory and thinking skills with age? A study in this week’s JAMA Internal Medicine suggests that it might. The findings come from a small substudy done as part of the PREDIMED trial, which showed that a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced heart attacks, strokes, and other cardiovascular problems among people at high risk for them. Although the results of the new PREDIMED study are promising, its small size and the fact that it wasn’t designed to look at connections between diet and brain health mean the results need to be taken with a grain of salt. That said, since there’s no downside to following a Mediterranean diet, an added bonus beyond great taste could be protecting memory and thinking skills.

Editorial calls for more research on link between football and brain damage

Patrick J. Skerrett, Former Executive Editor, Harvard Health

Is brain damage an inevitable consequence of American football, an avoidable risk of it, or neither? An editorial published yesterday in the medical journal BMJ poses those provocative questions. Chad Asplund, director of sports medicine at Georgia Regents University, and Thomas Best, professor and chair of sports medicine at Ohio State University, offer an overview of the unresolved connection between playing football and chronic traumatic encephalopathy, a type of gradually worsening brain damage caused by repeated mild brain injuries or concussions. The big question is whether playing football causes chronic traumatic encephalopathy or whether some people who play football already at higher risk for developing it. The Football Players Health Study at Harvard University hopes to provide a solid answer to that and other health issues that affect professional football players.

Cocoa: a sweet treat for the brain?

Heidi Godman
Heidi Godman, Executive Editor, Harvard Health Letter

There are many reasons why you might want to give someone chocolate on Valentine’s Day. There’s the tradition of it, and the idea of sweets for your sweetheart. Here’s another tempting reason: certain compounds in chocolate, called cocoa flavanols, have recently been linked with improved thinking skills. Italian researchers found people who drank a daily cocoa brew with a lot of flavanols (more than 500 milligrams) significantly improved their scores on tests that measured attention, executive function, and memory. How might cocoa flavanols boost thinking skills? They may help brain cells connect with each other. Dark chocolate is a good source of flavonols. It’s also a good source of calories. Adding it to your diet without taking out other foods can lead to weight gain, which may wipe out any health gain.

Memory slips in your 70s may be an early hint of future dementia

Julie Corliss
Julie Corliss, Executive Editor, Harvard Heart Letter

Of all the health issues that loom large with age, memory loss is among those that provoke the most worry. A big reason is the uncertainty: people often wonder if their occasional memory slips are just a normal part of growing old or a sign of impending Alzheimer’s disease, the most common form of dementia. A new study of older adults, published in today’s issue of the journal Neurology, sheds some light—and perhaps offers a bit of reassurance—about the connection between self-reported memory loss and a diagnosis of dementia. Over a 10-year period as 70-somethings turned into 80-somethings, about 1 in 6 developed dementia. About 80% had reported memory changes. But it took about nine years from the first self-report of a memory change to a diagnosis of mild cognitive impairment, an intermediate stage between normal memory loss and dementia. The transition to dementia usually took about 12 years.

Caffeine and a healthy diet may boost memory, thinking skills; alcohol’s effect uncertain

Stephanie Watson

A study published in this month’s Journal of Nutrition suggests that drinking caffeinated beverages, having the occasional alcoholic drink, and eating a healthy diet may help preserve memory and thinking skills long into old age. In particular, foods that are part of the Mediterranean diet—fruits, vegetables, nuts, fish, olive oil, and whole grains—show promise for preserving memory and preventing Alzheimer’s and other forms of dementia.