Amyloidosis is a disease in which an abnormal protein called amyloid accumulates in body tissues and organs. The protein deposits can be in a single organ or dispersed throughout the body. The disease causes serious problems in the affected areas. As a result, people with amyloidosis in different body parts may experience different physical problems:
Brain - Dementia
Heart - Heart failure, an irregular or unstable heart rhythm, enlarged heart
Kidneys - Kidney failure, protein in the urine
Nervous system - Numbness, tingling or weakness from nerve disease
Digestive system - Intestinal bleeding, intestinal obstruction, poor nutrient absorption
Blood - Low blood counts, easy bruising or bleeding
Pancreas - Diabetes
Musculoskeletal system - Joint pain or swelling, weakness
Skin - Lumps or purple discoloration
No one knows what causes amyloidosis. To make matters more complex, amyloidosis is not a single disease, and there are many different types of amyloid protein's that can be involved. For example, Alzheimer's disease and Creutzfeldt-Jakob disease (a rare cause of dementia linked to viruses living in livestock) are two distinct conditions characterized by amyloid deposits in the brain, but the proteins involved are different.
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